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KMID : 0644120150280010113
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Journal of Oriental Gynecology
2015 Volume.28 No. 1 p.113 ~ p.127
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Review on the Acne Related Articles Published in Korean Medical Journals - Focusing on Experimental Studies Published after 2005 -
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Yoon Hee-Jung
Kim Dong-Il
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Abstract
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Objectives: This study was performed to analyze the trend of acne-related experimental studies in Korean medicine.
Methods: We searched 17 articles related with experimental study of acne, published Korean medical journals from 2005 to 2014. We classified all articles according to the journal and checked on the kind of herbs. All articles were categorized into two types: cell experimental study and animal experimental study.
Results:
1. Total 17 papers were searched; 7 articles (41.2%) were published in the Journal of Korean Medical Ophthalmology, Otolaryngology, Dermatology, 4 articles (23.5%) were published in the Journal of Korean Institute of Pharmacopuncture, 3 articles (17.6%) were published in Korean Journal of Oriental Physiology and Pathology, 2 articles (11.8%) were published in Korean Journal of Herbology, and 1 article (5.9%) was published in the Journal of Korean Medicine.
2. Total 17 kind of herbs were used in the studies; 10 articles (58.8%) used single herb, 7 articles (41.2%) used complex herbs.
3. Total 17 articles were categorized 2 types; 16 cell experimental studies (94.1%), 1 animal experimental study (5.9%).
4. Experimental researches were mainly investigated using Raw 264.7 cell line and P. acnes. The levels of NO, iNOS, TNF-α, PGE, COX-2, IL-1β, IL-6, NF-kB were analyzed to confirm of herbs’ antibacterial, anti-inflammatory, antioxidant activity.
Conclusions: Searching for natural antibiotics, it is needed to do experimental studies continuously, and also needed to diversify the kind herbs and experimental bacteria.
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KEYWORD
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Acne, P. acnes, Anti-inflammation
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